As some of the comments above (which are really on the money) suggest it's a complicated question to answer because it is a case of "horses for courses" and that is even if we focus purely on straight-forward fuel efficiency. But given the programs that have been attempted (or are still ongoing) and also various studies it seems that ekranoplans seem to work best in two very distinct roles. Either as small, short range puddle-jumpers or as very large trans-oceanic monsters. For the later see also this which may well come to pass.
I guess at some level such utterly different roles is a problem for ekranoplan development. But, yes, in principle, there would certainly appear to be certain, very different niches, for which the ekranoplan is extremely competitive in terms of fuel consumption. Having said that the second niche is arguably also competing against conventional surface sea-freight which of course complicates matters but offers interesting possiblities. Aircraft like the Boeing Pelican (which didn't get past concept stage) was designed not for standard air-cargo pallets but for ISO containers. Now that capability is a real game changer as long as the cost per kg/km fuel economy is as good or better than a conventional air-freighter which I suspect is very doable. At least in principle.